' 
SCIENTIFIC SCORE
Possibly Effective
Based on 51 Researches
7.2
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 1 Soft Gel
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
1%**
Cholesterol
<5mg
<2%
Vitamin A (from cod live oil and retinyl palmitate)
27 mcg RAE
3%
Vitamin D (as cholecalciferol) (from cod liver oil and cholecalciferol concentrate)
100 mcg (4,000 IU)
500%
Vitamin E (as d-alpha tocopherol)
0.67 mg
4%
Norwegian Cod Liver Oil
500 mg
†
Total Omega-3 fatty Acids☆
115 mg
†
DHA (Docosahexaenoic Acid)☆
50 mg
†
EPA (Eicosapentaenoic Acid)☆
42 mg
†
Top Medical Research Studies
8
Vitamin D and breast cancer link
Umbrella Review on the Relationship Between Vitamin D Intake and Cancer.
Directly addresses breast cancer benefits
We examined the relationship between vitamin D intake and breast cancer, delving into how this vitamin may play a role in prevention and management. The findings suggest that vitamin D may have a protective effect, potentially lowering the risk of developing breast cancer.
While we found a notable connection, it’s important to recognize that most of the existing evidence comes from observational studies. This means we can identify associations but cannot definitively say that vitamin D causes these effects.
Additionally, there are several complexities in studying vitamin D, such as varying metabolism and differences in study designs, which make drawing firm conclusions challenging.
Although the research provides intriguing insights, more rigorous studies are necessary to truly clarify how vitamin D could be integrated into breast cancer care moving forward.
While we found a notable connection, it’s important to recognize that most of the existing evidence comes from observational studies. This means we can identify associations but cannot definitively say that vitamin D causes these effects.
Additionally, there are several complexities in studying vitamin D, such as varying metabolism and differences in study designs, which make drawing firm conclusions challenging.
Although the research provides intriguing insights, more rigorous studies are necessary to truly clarify how vitamin D could be integrated into breast cancer care moving forward.
Read More
8
Vitamin D impacts breast cancer outcomes
Impact of Vitamin D Levels on Progression-Free Survival and Response to Neoadjuvant Chemotherapy in Breast Cancer Patients: A Systematic Review and Meta-Analysis.
Highly relevant to breast cancer research
We explored how vitamin D (VD) levels might impact breast cancer (BC) patients undergoing neoadjuvant chemotherapy (NACT). The study reviewed data from six different research projects involving patients who had confirmed diagnoses of BC and had their vitamin D levels measured before starting chemotherapy.
Our analysis revealed some intriguing findings. Specifically, maintaining adequate vitamin D levels appeared to lower the chances of not responding to neoadjuvant chemotherapy by 22%. Additionally, those with sufficient vitamin D experienced a 35% reduced risk of disease progression compared to those with low or deficient levels. This suggests that vitamin D might play a beneficial role in improving treatment outcomes for breast cancer patients.
Overall, these results underscore the importance of keeping vitamin D levels within a healthy range during cancer treatment. They encourage us to delve deeper into how vitamin D influences cancer biology and its potential as a supportive therapy in breast cancer management.
Our analysis revealed some intriguing findings. Specifically, maintaining adequate vitamin D levels appeared to lower the chances of not responding to neoadjuvant chemotherapy by 22%. Additionally, those with sufficient vitamin D experienced a 35% reduced risk of disease progression compared to those with low or deficient levels. This suggests that vitamin D might play a beneficial role in improving treatment outcomes for breast cancer patients.
Overall, these results underscore the importance of keeping vitamin D levels within a healthy range during cancer treatment. They encourage us to delve deeper into how vitamin D influences cancer biology and its potential as a supportive therapy in breast cancer management.
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5
Vitamin D's impact on muscle strength
Low Serum Vitamin D Levels Are Associated with Reduced Muscle Strength in Women with Breast Cancer.
Highly relevant breast cancer study
We explored the connection between vitamin D levels and muscle strength in women with breast cancer. This research involved adult women who had been diagnosed with breast cancer within the last 12 months, ensuring that none had metastases or recurrences. Our focus was on understanding how inadequate vitamin D might relate to reduced muscle strength in this specific group.
We discovered that a significant portion of the participants, around 70%, had insufficient levels of vitamin D. This deficiency was notably linked to lower muscle strength, as indicated by the Handgrip Strength test. Specifically, the findings showed that women with insufficient vitamin D were more likely to fall into the lower muscle strength categories.
The study sheds light on the importance of monitoring vitamin D levels in women battling breast cancer. Given the link between low vitamin D and weaker muscle strength, addressing this deficiency might offer a new avenue for improving overall health and vitality in these patients.
We discovered that a significant portion of the participants, around 70%, had insufficient levels of vitamin D. This deficiency was notably linked to lower muscle strength, as indicated by the Handgrip Strength test. Specifically, the findings showed that women with insufficient vitamin D were more likely to fall into the lower muscle strength categories.
The study sheds light on the importance of monitoring vitamin D levels in women battling breast cancer. Given the link between low vitamin D and weaker muscle strength, addressing this deficiency might offer a new avenue for improving overall health and vitality in these patients.
Read More
Most Useful Reviews
9.5
Remarkable improvement
Excellent! My wife, diagnosed with breast cancer, has shown remarkable improvement since using products recommended by Dr Antti Heikkilä. She feels stronger and can walk a bit and manage some home tasks. It's almost miraculous, as she now believes she might have more time to live. In November 2010, an oncologist gave her just two months to live, but thanks to Dr Heikkilä's advice and the items from iherb.com, she has gained precious time. Thank you for everything!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 51 Researches
7.2
- All Researches
9.5
Impact of DIM formulations on cancer
Comparative preclinical pharmacokinetics study of 3,3'-diindolylmethane formulations: is personalized treatment and targeted chemoprevention in the horizon?
Partially diminished relevance due to formulation
We delved into how different formulations of 3,3'-diindolylmethane (DIM) could impact breast cancer prevention, particularly exploring a liquid DIM formulation that included cod liver oil. During our study, we compared this oil-based solution to crystalline DIM and found that the oil formulation significantly boosted DIM's presence in the bloodstream—showing a fivefold increase in bioavailability.
Despite this promising result for DIM itself, it's important to note that the study did not isolate the specific impact of cod liver oil on breast cancer development. Therefore, while the findings are intriguing and suggest potential benefits for the DIM formulations, we cannot conclusively say that cod liver oil alone shows significant effects against breast cancer.
Further research is necessary to clarify this relationship, especially for patients with certain genetic predispositions to breast cancer, like those with BRCA1 mutations.
Despite this promising result for DIM itself, it's important to note that the study did not isolate the specific impact of cod liver oil on breast cancer development. Therefore, while the findings are intriguing and suggest potential benefits for the DIM formulations, we cannot conclusively say that cod liver oil alone shows significant effects against breast cancer.
Further research is necessary to clarify this relationship, especially for patients with certain genetic predispositions to breast cancer, like those with BRCA1 mutations.
Read More
9.5
Effective DHA and DTX combination
Improved Antitumor Efficacy of a Dextran-based Docetaxel-coupled Conjugate against Triple-Negative Breast Cancer.
Relevant to DHA's cancer effects
We explored the effectiveness of a new treatment strategy for breast cancer that combines docosahexaenoic acid (DHA) with docetaxel (DTX). In our study, we developed a dextran-based dual-drug conjugate that allows these two compounds to work together more effectively against breast cancer cells.
The conjugate we created showed promise in our tests, especially against triple-negative breast cancer, which is often more challenging to treat. We discovered that this new formulation not only improved the water solubility of DTX but also enabled it to reach the tumor more effectively, minimizing distribution to normal tissues.
Results demonstrated that this combination significantly inhibited tumor growth compared to traditional DTX treatments, nearly eliminating tumors in our mouse model without causing adverse systemic effects. This work suggests that when DHA is coupled with DTX, it enhances the potential for improved breast cancer treatments.
The conjugate we created showed promise in our tests, especially against triple-negative breast cancer, which is often more challenging to treat. We discovered that this new formulation not only improved the water solubility of DTX but also enabled it to reach the tumor more effectively, minimizing distribution to normal tissues.
Results demonstrated that this combination significantly inhibited tumor growth compared to traditional DTX treatments, nearly eliminating tumors in our mouse model without causing adverse systemic effects. This work suggests that when DHA is coupled with DTX, it enhances the potential for improved breast cancer treatments.
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9
DHA impacts breast cancer survivors
Randomized dose-response trial of n-3 fatty acids in hormone receptor negative breast cancer survivors- impact on breast adipose oxylipin and DNA methylation patterns.
Direct investigation of DHA effects
We investigated how docosahexaenoic acid (DHA), along with eicosapentaenoic acid (EPA), affects women who have survived hormone receptor-negative (ERPR-) breast cancer. Our study focused on a randomized controlled trial involving participants who had completed standard treatment within the past five years. We compared the effects of two different doses of DHA and EPA supplementation over a year—one higher at around 5 grams per day and another lower at about 1 gram per day.
Throughout the 12-month period, we collected blood and breast adipose tissue samples every three months to analyze various biomarkers. What we observed was a dose-dependent increase in the levels of these fatty acids and their biological metabolites, known as oxylipins. Notably, this increase corresponded with changes in DNA methylation patterns in the gene promoters associated with metabolism pathways that are crucial in the development and progression of ERPR- breast cancer.
Our findings suggest that high doses of EPA and DHA not only influence the fatty acid profiles in breast adipose tissue but also impact genetic expression linked with breast cancer progression. This research opens new avenues for understanding how n-3 fatty acids could play a role in preventing ERPR- breast cancer through both metabolic and epigenetic means.
Throughout the 12-month period, we collected blood and breast adipose tissue samples every three months to analyze various biomarkers. What we observed was a dose-dependent increase in the levels of these fatty acids and their biological metabolites, known as oxylipins. Notably, this increase corresponded with changes in DNA methylation patterns in the gene promoters associated with metabolism pathways that are crucial in the development and progression of ERPR- breast cancer.
Our findings suggest that high doses of EPA and DHA not only influence the fatty acid profiles in breast adipose tissue but also impact genetic expression linked with breast cancer progression. This research opens new avenues for understanding how n-3 fatty acids could play a role in preventing ERPR- breast cancer through both metabolic and epigenetic means.
Read More
9
DHA impacts breast cancer immunity
Docosahexaenoic acid (DHA) impairs hypoxia-induced cellular and exosomal overexpression of immune-checkpoints and immunomodulatory molecules in different subtypes of breast cancer cells.
Directly relevant DHA effects
We explored the role of docosahexaenoic acid (DHA), an omega-3 fatty acid, in altering the behavior of breast cancer cells, specifically focusing on how it impacts immune responses. Cancer cells often use immune-checkpoint molecules to evade our body’s natural defenses, and this study looked at whether DHA could influence the expression of these critical molecules.
By treating two types of breast cancer cells—MDA-MB-231 (triple negative) and BT-474 (triple positive)—with DHA under both normoxic and hypoxic (low oxygen) conditions for 24 hours, we observed notable changes. The study showed that hypoxia caused a significant increase in immune-checkpoints and immunomodulatory molecules. However, when we introduced DHA, the results were promising: there was a marked decrease in the expression of those immune markers.
Additionally, the treatment with DHA also led to an increase in regulatory microRNAs, which are important for controlling the immune response. These results suggest that DHA might play a supportive role in breast cancer therapy by reducing the mechanisms that allow cancer cells to escape immune surveillance. This could open pathways for new treatment options that integrate nutritional interventions like DHA supplementation alongside traditional cancer therapies.
By treating two types of breast cancer cells—MDA-MB-231 (triple negative) and BT-474 (triple positive)—with DHA under both normoxic and hypoxic (low oxygen) conditions for 24 hours, we observed notable changes. The study showed that hypoxia caused a significant increase in immune-checkpoints and immunomodulatory molecules. However, when we introduced DHA, the results were promising: there was a marked decrease in the expression of those immune markers.
Additionally, the treatment with DHA also led to an increase in regulatory microRNAs, which are important for controlling the immune response. These results suggest that DHA might play a supportive role in breast cancer therapy by reducing the mechanisms that allow cancer cells to escape immune surveillance. This could open pathways for new treatment options that integrate nutritional interventions like DHA supplementation alongside traditional cancer therapies.
Read More
9
DHA enhances doxorubicin efficacy
n-3 PUFAs synergistically enhance the efficacy of doxorubicin by inhibiting the proliferation and invasion of breast cancer cells.
Moderate relevance to breast cancer
We examined how docosahexaenoic acid (DHA), along with eicosapentaenoic acid (EPA), can work in synergy with the chemotherapy drug doxorubicin (DOXO) to enhance its effectiveness against breast cancer. Through our study using the MCF-7 breast cancer cell line, we discovered that combining n-3 polyunsaturated fatty acids with DOXO significantly increased cell death in cancer cells compared to DOXO alone.
Importantly, we also observed a reduction in cancer cell migration, indicating that the combination treatment may not only kill cancer cells but also help prevent their spread. The cell cycle analysis showed that the cells treated with both DHA and DOXO had a stronger halt in the G1 phase, which suggests a more powerful prevention of cancer cells moving towards division.
Our findings suggest that integrating n-3 PUFAs with traditional chemotherapy could be a promising approach to improving treatment outcomes for breast cancer. This combination appears to restrain both the growth and the ability of breast cancer cells to invade other tissues.
Importantly, we also observed a reduction in cancer cell migration, indicating that the combination treatment may not only kill cancer cells but also help prevent their spread. The cell cycle analysis showed that the cells treated with both DHA and DOXO had a stronger halt in the G1 phase, which suggests a more powerful prevention of cancer cells moving towards division.
Our findings suggest that integrating n-3 PUFAs with traditional chemotherapy could be a promising approach to improving treatment outcomes for breast cancer. This combination appears to restrain both the growth and the ability of breast cancer cells to invade other tissues.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Remarkable improvement
Excellent! My wife, diagnosed with breast cancer, has shown remarkable improvement since using products recommended by Dr Antti Heikkilä. She feels stronger and can walk a bit and manage some home tasks. It's almost miraculous, as she now believes she might have more time to live. In November 2010, an oncologist gave her just two months to live, but thanks to Dr Heikkilä's advice and the items from iherb.com, she has gained precious time. Thank you for everything!
Read More
